Abstract: In order to generate design-spectrum-compatible artificial seismic waves more efficiently and rationally, three problems that arise during the procedure of artificial seismic signals generation are studied and discussed in this paper by the aid of an earthquake signal processing software named EQSignal which is developed by the authors, and through the response analysis of harmonic resonance system with single degree of freedom, the corresponding suggestions to solve these questions are also provided. It is suggested that transfer function method should be adopted within the high-frequency segment of a response spectrum, and step-by-step integration method can be used within the low-frequency segment. There should be more than 120 period points in a seismic response spectrum, and the period points should be log-uniformly distributed at short-period segment and uniformly distri-buted at long-period segment. During seismic spectrum fitting, both the two iterative methods in frequency domain and time domain are recommended to use in order to give consideration to both efficiency and convergence.