Abstract: In this paper, the concentrations of total mercury, total organic carbon and major elements of soil in the surface rupture zone of Anninghe fault zone were analyzed. The results showed that the peak distribution of total mercury was consistent with that of soil gas mercury in Xiaomiao and Zimakua area, which may reveal the channel location of mercury released from the fault. The correlation coefficient between total mercury and total organic carbon in the soil vertical profiles of Xiaomiao, Yangfushan, Yejidong and Zimakua indicated that, total organic carbon was an important factor to control the distribution of total mercury concentration in the soil. The correlation coefficient among total mercury, total organic carbon and CIA index and vertical distribution of mercury concentration indicated that the sources of mercury in the soil profiles were affected by interference, background and the fault degassing. This study provides a reference for analyzing the relationship between distribution of mercury and tectonic activity.