Abstract: In order to explore the application of large-capacity airgun source in deep seismic reflection exploration, airgun flowing excitation experiment was carried out in the Tongling area of Anhui Province in October of 2015. The experiment adopts the working mode that the source is excited in Yangtze River channel and reflected signal is received in a fixed array along the shore. Due to the influence of the Yangtze River channel and river bank topography, coupled with development of interference wave and the prominent problem of static correction in the original records, the conventional processing method of common middle point superposition is no longer applicable in this region. Therefore, we carried out a targeted research on data processing methods. And a series of processing methods are applied, such as tomographic static correction, multi-domain and multi-channel joint de-noising and common reflection surface stacking of non-longitudinal bending line data. The results show that the obtained stacking section of deep structure is clear in the area where the survey line passes through. The results of this study can provide technical support and methodological reference for similar researches in other rivers using airgun source in the future.