Abstract: This paper introduced the design ideas and function implementation of ionospheric multi-parameter anomaly monitoring system in Sichuan-Yunnan region, and then applied the system to monitoring test of the M_S6.0 earthquake on June 17, 2019 in Changning, Sichuan. The results show that the system realizes the real-time monitoring of abnormal changes such as global and China regional VTEC, site VTEC and f_oF₂, which is helpful to carry out the demonstrative seismic-ionospheric anomaly monitoring. The graphic and data results can provide evidences for the identification of seismic-ionospheric anomalous disturbance, and ionospheric precursor information for earthquake monitoring and prediction in Sichuan-Yunnan region.