Abstract: In this paper, a typical two-story and three-span subway station is taken as the research object. The nonlinear dynamic time-history analysis method is adopted to conduct numerical simulation analysis on the model of the subway station and the upper bridge on soft site. A potential coupling failure mode of subway station and bridge is presented. The seismic interaction between the subway station and the upper bridge is studied. Numerical simulation results show that: the bridge has a little effect on the seismic response of the station, and the damage of the station mainly depends on the earthquake action and structure strength; the destruction of the subway station will cause a large horizontal and vertical deformation of the soil in adjacent areas, resulting in the bridge beam fall; after the destruction of the station, the bridge foundation makes the soil move towards the station, which aggravates the earthquake damage of subway station.