Abstract: The M_S6.4 （M_W6.1） earthquake occurred on May 21, 2021 in Yangbi county, Yunnan, China is the main shock of a typical foreshock-mainshock-aftershock sequence. This research carried out a preliminary study focusing on tectonic background, double-difference hypocenter location, moment tensor and rupture directivity of major earthquakes, stress field and fault slip-tendency, as well as tidal effect. According to the results of moment tensor inversion and rupture directivity of the main shock and the distribution of aftershocks, it is determined that the source faults of the main shock has strike 137°, dip 75°, rake −167°. The centroid depth of the main shock is 6.0 km, and the fault ruptured unilaterally toward the south-east direction, showing pure double-couple mechanism with dominant right-lateral strike-slip and minor normal components. Relocated hypocenters show that the Yangbi earthquake sequence is located near, but significantly departs from the well-known Qiaohou-Weishan fault in the northern segment of the Honghe fault zone, demonstrating an unmapped NW-trending strike-slip fault （we named “Yangbi fault” in this paper） with some small scale conjugate faults of NE-trending. The hypocenters are distributed along the NW-trending major fault, but also exhibit clusters along the NE-trending faults. The strongest foreshocks and most of the major aftershocks were caused by rupture of NE-trending source faults. All major earthquakes show a unilateral rupture directivity. We have obtained reliable mechanism solutions of more than 20 events with M_W＞3.4 in the focused area （within 15 km of the center of the Yangbi earthquake sequence）, which enabled us to be able to invert the mean stress field in the area. The principal stress shape ratio φ＝（σ₂－σ₃）/（σ₁－σ₃） is 0.46±0.17; the （azimuth, plunge） of the maximum, intermediate, and minimum principal stress axes are （188.0°±9.0°, 12.4°±7.0°）, （50°±45°, 72.1°±11.3°）, and （280.3°±7.0°, 10.4°±12.0°）, respectively. Through theoretical tidal strain and stress analysis, it is found that this seismic sequence is significantly affected by tidal modulation. The first major earthquakes of the foreshock clusters that began at 18:00−20:00 on May 18 and 19 and the main shock occurred near the peaks of tidal volumetric strain and Coulomb failure stress. Based on the focal mechanism solutions of the main earthquakes, the distributions of foreshocks and aftershocks, the facts of tidal modulation, the rupture directivity of major earthquakes, fault slip-tendency analysis, and the results of previous studies on similar seismic activities in northwestern Yunnan, we preliminarily suggest that the Yangbi earthquake sequence is significantly affected by the action of deep fluids. The first foreshock activity climax at 18:00 on 18 May, in a tensile fault step （should be permeable channel） area of the NW-trending fault, likely initiated along NE-trending faults （greater slip-tendency） by deep overpressure fluid, and then migrated to the northwest. The second climax of foreshock activity that began at night on the 19 May was concentrated near the hypocenter of the main shock. The triggering of these foreshocks and the action of deep fluid jointly promoted the activity of the NW-trending fault （smaller slip-tendency）, but the main shock was mainly promoted by the action of deep fluid.