Abstract: A M_S6.0 earthquake with a focal depth of 16 km occurred with the epicenter of （28.34°N, 104.90°E） in Changning county, Yibin city, Sichuan Province on June 17, 2019. There were three strong aftershocks above M_S5.0 within five days after the Changning earthquake and another M_S5.6 earthquake occurred in Gongxian County on July 4. This paper relocated 1948 M_L≥2.0 earthquakes in Changning-Xingwen area during 2019 to 2020 by the double difference method based on the seismic phase observation report provided by China Earthquake Networks Center. The distribution of 1 823 earthquakes above M_L2.0 after relocation shows that the aftershock sequence in the northern area of Changning spreads along the NW−SE direction anticline. Moreover, the earthquakes in southern area is more scattered. We calculated source parameters such as seismic moment and stress drop based on 208 earthquakes above M_L3.0 in Changning-Xingwen area, Sichuan from 17 June 2019 to 31 December 2020, and analyzed the evolution characteristics of seismic stress drop in the region before and after the Changning M_S6.0 earthquake on June 17, 2019. The results show that the stress drop of M_L3.0−3.9 earthquakes significantly increased in Changning-Xingwen area before the moderate strong aftershocks, and most of the earthquakes above M_L4.0 occurred in the high stress drop area of M_L3.0−3.9 earthquakes in the study area.