Abstract: The dynamic response of the anti-seismic structure and the seismic isolation structure Coupled equipment under the action of seismic waves with different time-frequency characteristics is studied, and the wavelet analysis of the test data of the five-layer steel frame shaking table model is carried out. The results show that: the dynamic response of the main structure is directly related to the time-frequency characteristics of seismic waves; due to the filtering effect of the main structure and seismic isolation bearings, the dynamic response of the equipment is significantly affected by the time-frequency characteristics of seismic waves, but there is no direct correlation; isolation can reduce the amplification coefficient of the equipment by moving the frequency of the device away from the frequency of the main structure; the variation trend of the acceleration of the main structure after coupling the equipment depends on the seismic wave energy distribution with different time-frequency characteristics.